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Article

The CC chemokine receptor 4 as a novel specific molecular target for immunotherapy in adult T-Cell leukemia/lymphoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2004

Ishida Takashi, Iida Shinsuke, Akatsuka Yoshiki, Ishii Toshihiko, Miyazaki Mikinori, Komatsu Hirokazu, Inagaki Hiroshi, Okada Noriko, Fujita Teizo, Shitara Kenya, Akinaga Shiro, Takahashi Toshitada, Utsunomiya Atae, Ueda Ryuzo

Abstract excerpt

Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell neoplasm with dismal prognosis, and no optimal therapy has been developed. We tested the defucosylated chimeric anti-CC chemokine receptor 4 (CCR4) monoclonal antibody, KM2760, to develop a novel immunotherapy for this refractory tumor. In the presence of peripheral blood mononuclear cells (PBMCs) from healthy adult donors, KM2760 induced CCR4-specific...

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Source

Identifiers

PMID: 15569983
DOI: 10.1158/1078-0432.CCR-04-0983

Genes

CCR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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