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Pioglitazone administration restores a PPARG-dependent transcriptional network and ATP levels within skeletal muscles of mice implanted with patient-derived breast tumors

2021-10-04

Abstract excerpt

<h4>Background</h4> Fatigue is common in patents with breast cancer (BC), and can occur in patients with early stage disease and in the absence of muscle wasting (i.e. cachexia). We have reported transcriptional and proteomic alterations in muscles from BC patients, which are associated with fatigue. Mice implanted with human BC xenografts recapitulate the muscle molecular composition changes seen in patients, co...

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Identifiers and source

Literature Corpus work
0672e9de-cdab-5691-8add-dc6a4bc0b852
DOI
10.1101/2021.10.04.463044
Open publication

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Pioglitazone administration restores a PPARG-dependent transcriptional network and ATP levels within skeletal muscles of mice implanted with patient-derived breast tumorsDOI 10.1101/2021.10.04.463044
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