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Article

Structural basis for ACT1 oligomerization induced by IL-17 receptor hetero-tetramer

2025-12-05

Abstract excerpt

The IL-17 receptors (IL-17Rs) play critical roles in immunity and inflammatory diseases. IL-17-induced heteromeric complexes between IL-17RA and another IL-17R trigger signaling by binding the downstream transducer ACT1 through interactions between their intracellular SEF/IL-17R (SEFIR) domains. The molecular mechanism of this process remains unclear. Here we present the cryo-EM structure of the complex of IL-17RA...

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Literature Corpus work
064b84ab-b564-5c1f-8908-a14e24ab251d
DOI
10.64898/2025.12.02.691943
Open publication

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Structural basis for ACT1 oligomerization induced by IL-17 receptor hetero-tetramerDOI 10.64898/2025.12.02.691943
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