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Effects of Sarcosine (N-Methylglycine) on NMDA Receptor Hypofunction Induced by MK801: <em>In Vivo</em> Calcium Imaging in the CA1 Region of the Dorsal Hippocampus

2024-10-28

Abstract excerpt

Hypofunction of the glutamate system in the brain is one of the pathophysiological hypotheses for schizophrenia. Accumulating animal and clinical studies show that sarcosine (N-methylglycine), a glycine transporter-1 inhibitor, is effective for ameliorating the negative and cognitive symptoms of schizophrenia. The aims of the present study were to observe the effects of sarcosine on neuronal activity in the dorsal...

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Literature Corpus work: 061cf914-cbdd-53fa-9504-6127c2e8324e
DOI: 10.20944/preprints202410.2148.v1

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