Article

AT7867 promotes pancreatic progenitor differentiation of human iPSCs and accelerates diabetes reversal

2023-05-12

Abstract excerpt

<h4>Summary</h4> Generation of pure pancreatic progenitor cells (PPs) is critical for clinical translation of stem cell derived islets. Herein, we performed PP differentiation with and without AKT/P70 inhibitor AT7867 and characterized the resulting cells at protein and transcript level in vitro and in vivo upon transplantation into diabetic mice. AT7867 treatment increased the percentage of PDX1 + NKX6.1 + (...

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Literature Corpus work: 060e1e9e-8de6-5111-80a3-36c34f9335d2
DOI: 10.1101/2023.05.11.538780

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