Article

GP2-enriched pancreatic progenitors give rise to functional beta cells <i>in vivo</i> and eliminate the risk of teratoma formation

2021-05-16

Abstract excerpt

<h4>Summary</h4> Human pluripotent stem cell (hPSC)-derived pancreatic progenitors (PPs) can be differentiated into beta-like cells in vitro and in vivo , and therefore have therapeutic potential for type 1 diabetes (T1D) treatment. However, the purity of PPs varies across different hPSC lines, differentiation protocols and laboratories. The uncommitted cells may give rise to non-pancreatic endodermal, mesoderm...

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Literature Corpus work: 12409fda-269e-58b2-b926-874de94f0d66
DOI: 10.1101/2021.05.15.444293

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