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Article

Dysregulated heparan sulfate proteoglycan metabolism promotes Ewing sarcoma tumor growth

2021-05-27

Abstract excerpt

The Ewing sarcoma family of tumors is a group of malignant small round blue cell tumors (SRBCTs) that affects children, adolescents and young adults. The tumors are characterized by reciprocal chromosomal translocations that generate chimeric fusion oncogenes, the most common of which is EWSR1-FLI1. Survival is extremely poor for patients with metastatic or relapsed disease, and no molecularly-targeted therapy for...

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Literature Corpus work
44762e30-2155-574b-8e9f-8c3b039ad567
DOI
10.1101/2021.05.25.445683
Open publication

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Dysregulated heparan sulfate proteoglycan metabolism promotes Ewing sarcoma tumor growthDOI 10.1101/2021.05.25.445683
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