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Article

Phenotypic consequences of somatic mutations in the ataxia-telangiectasia mutated gene in non-small cell lung cancer.

Oncotarget - 20 Sept 2016

Weber Anika Maria, Drobnitzky Neele, Devery Aoife Maire, Bokobza Sivan Mili, Adams Richard A, Maughan Timothy S, Ryan Anderson Joseph

Abstract excerpt

Mutations in the Ataxia-telangiectasia mutated (ATM) gene are frequently found in human cancers, including non-small cell lung cancer (NSCLC). Loss of ATM function confers sensitivity to ionising radiation (IR) and topoisomerase inhibitors and may thus define a subset of cancer patients that could get increased benefit from these therapies. In this study, we evaluated the phenotypic consequences of ATM missense...

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Source

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Identifiers

PMID: 27602502
DOI: 10.18632/oncotarget.11845
PMCID: PMC5308618

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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