Article

Early immune pressure imposed by tissue resident memory T cells sculpts tumour evolution in non-small cell lung cancer

2021-04-21

Abstract excerpt

Tissue-resident memory T cells (T RM ) provide immune defence against local infection and can inhibit cancer progression. However, it is unclear to what extent chronic inflammation impacts T RM activation and how the immune pressure exerted by T RM affects developing tumours in humans. We performed deep profiling of lung cancers arising in never-smokers (NS) and ever-smokers (ES), finding evidence of enhanced T...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 05d6c5ef-8222-506d-99d0-b2ca83bdf28f
DOI: 10.1101/2021.04.20.440373

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Early immune pressure imposed by tissue resident memory T cells sculpts tumour evolution in non-small cell lung cancerDOI 10.1101/2021.04.20.440373Read

Early immune pressure imposed by tissue resident memory T cells sculpts tumour evolution in non-small cell lung cancerSemantic proximity Read

Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular featuresSemantic proximity Read

Genomic and immune heterogeneity of multiple synchronous lung adenocarcinoma at different developmental stages.Semantic proximity Read

New evaluation of the tumor immune microenvironment of non-small cell lung cancer and its association with prognosisSemantic proximity Read

Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular featuresSemantic proximity Read

The Single-Cell Immunogenomic Landscape of B and Plasma Cells in Early-Stage Lung AdenocarcinomaSemantic proximity Read

Immune surveillance in clinical regression of pre-invasive squamous cell lung cancerSemantic proximity Read

Common origin for effector and regulatory follicular and tissue-Adapted CD4+ T cells in Non-Small Cell Lung CancerSemantic proximity Read

Intratumoural heterogeneity and immune modulation in lung adenocarcinoma of female smokers and never smokersSemantic proximity Read

The T cell differentiation landscape is shaped by tumour mutations in lung cancer.Semantic proximity Read

Large scale analysis of smoking-induced changes in the tumor immune microenvironmentSemantic proximity Read

In situ programming of intratumoural stem cell-like memory CD8⁺ T cells enables durable antitumour immunity in immunosuppressive tumoursSemantic proximity Read