Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dual inhibition of HDAC and EGFR signaling with CUDC-101 induces potent suppression of tumor growth and metastasis in anaplastic thyroid cancer.

Oncotarget - 20 Apr 2015

Zhang Lisa, Zhang Yaqin, Mehta Amit, Boufraqech Myriem, Davis Sean, Wang Jing, Tian Ze, Yu Zhiya, Boxer Matthew B, Kiefer Jeffrey A, Copland John A, Smallridge Robert C, Li Zhuyin, Shen Min, Kebebew Electron

Abstract excerpt

Anaplastic thyroid cancer (ATC) is one of the most lethal human malignancies that currently has no effective therapy. We performed quantitative high-throughput screening (qHTS) in three ATC cell lines using 3,282 clinically approved drugs and drug candidates, and identified 100 active agents. Enr...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma
Share to High-Throughput Screening Assays

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Deacetylase Inhibitors

Share to Hydroxamic Acids

Share to Quinazolines

Share to Receptor, ErbB-2

Share to Small Molecule Libraries

Share to Xenograft Model Antitumor Assays

Source

Open in PubMed Open full text

Identifiers

PMID: 25940539
DOI: 10.18632/oncotarget.3268
PMCID: PMC4496203

Genes

EGFR
XIAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25940539-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dual inhibition of HDAC and EGFR signaling with CUDC-101 induces potent suppression of tumor growth and metastasis in anaplastic thyroid cancer.PMID 25940539Read ↗

Carfilzomib potentiates CUDC-101-induced apoptosis in anaplastic thyroid cancer.Semantic proximity Read ↗

Inhibition of Survivin with YM155 Induces Durable Tumor Response in Anaplastic Thyroid CancerSemantic proximity Read ↗

HDAC1 and HDAC2 Double Knockout Triggers Cell Apoptosis in Advanced Thyroid CancerSemantic proximity Read ↗

Anaplastic thyroid cancer: molecular pathogenesis and emerging therapiesSemantic proximity Read ↗

CUDC-101, a Multitargeted Inhibitor of Histone Deacetylase, Epidermal Growth Factor Receptor, and Human Epidermal Growth Factor Receptor 2, Exerts Potent Anticancer ActivitySemantic proximity Read ↗

Advances in targeted therapy for anaplastic thyroid carcinoma.Semantic proximity Read ↗

Dramatic clinical response to dabrafenib plus trametinib in anaplastic thyroid carcinoma and the challenges faced during the COVID-19 pandemic.Semantic proximity Read ↗

Differentiated thyroid cancers: a comprehensive review of novel targeted therapies.Semantic proximity Read ↗

A Novel Liver Cancer-Selective Histone Deacetylase Inhibitor Is Effective Against Hepatocellular Carcinoma and Induces Durable Responses with ImmunotherapySemantic proximity Read ↗

Outcome of initial lenvatinib treatment in patients with unresectable anaplastic thyroid cancerSemantic proximity Read ↗

Evaluating new treatments for anaplastic thyroid cancer.Semantic proximity Read ↗

HDAC inhibitors target IRS4 to enhance anti-androgen receptor (AR) therapy in AR-positive triple negative breast cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.