Article

COVID-19 infection induces readily detectable morphological and inflammation-related phenotypic changes in peripheral blood monocytes, the severity of which correlate with patient outcome

2020-03-26

Abstract excerpt

<h4>Background</h4> Excessive monocyte/macrophage activation with the development of a cytokine storm and subsequent acute lung injury, leading to acute respiratory distress syndrome (ARDS) is a feared consequence of infection with COVID-19. The ability to recognize and potentially intervene early in those patients at greatest risk of developing this complication could be of great clinical utility. <h4>Methods</h...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 05a94c25-a01b-5029-87e1-29ccb5c886e6
DOI: 10.1101/2020.03.24.20042655

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

COVID-19 infection induces readily detectable morphological and inflammation-related phenotypic changes in peripheral blood monocytes, the severity of which correlate with patient outcomeDOI 10.1101/2020.03.24.20042655Read

Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severitySemantic proximity Read

Alterations in Circulating Monocytes Predict COVID-19 Severity and Include Chromatin Modifications Still Detectable Six Months after RecoverySemantic proximity Read

Monocytes and Macrophages in COVID-19Semantic proximity Read

Longitudinal peripheral blood transcriptional analysis of COVID-19 patients captures disease progression and reveals potential biomarkersSemantic proximity Read

Innate immune deficiencies in patients with COVID-19Semantic proximity Read

Analysis of respiratory and systemic immune responses in COVID-19 reveals mechanisms of disease pathogenesisSemantic proximity Read

Monocyte-Driven Atypical Cytokine Storm and Aberrant Neutrophil Activation as Key Mediators of COVID19 Disease SeveritySemantic proximity Read

Dynamic changes in monocytes subsets in COVID-19 patients.Semantic proximity Read

Heightened Circulating Interferon-Inducible Chemokines, and Activated Pro-Cytolytic Th1-Cell Phenotype Features Covid-19 Aggravation in the Second Week of Illness.Semantic proximity Read

Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature upon SARS-CoV-2 sensing by monocytes in COVID-19Semantic proximity Read

Transcriptional Changes in CD16+ Monocytes May Contribute to the Pathogenesis of COVID-19Semantic proximity Read

Viral load is associated with mitochondrial dysfunction and altered monocyte phenotype in acute severe SARS-CoV-2 infection.Semantic proximity Read