Article
Heightened Circulating Interferon-Inducible Chemokines, and Activated Pro-Cytolytic Th1-Cell Phenotype Features Covid-19 Aggravation in the Second Week of Illness.
Frontiers in immunology - 1 Jan 2020
Tincati Camilla, Cannizzo E Stefania, Giacomelli Mauro, Badolato Raffaele, d'Arminio Monforte Antonella, Marchetti Giulia
Abstract excerpt
Covid-19 features a delayed onset of critical illness occurring approximately one week from the beginning of symptoms, which corresponds to the bridging of innate and adaptive immunity. We reasoned that the immune events occurring at the turning point of disease might mark the direction toward pathogenic versus protective inflammatory responses. Subjects with either severe (s; PaO2/FiO2 ratio <200) or mild (m;...
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