Viral load is associated with mitochondrial dysfunction and altered monocyte phenotype in acute severe SARS-CoV-2 infection.

doi:10.1016/j.intimp.2022.108697

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Article

Viral load is associated with mitochondrial dysfunction and altered monocyte phenotype in acute severe SARS-CoV-2 infection.

International immunopharmacology - 1 Jul 2022

Romão Pedro Rt, Teixeira Paula C, Schipper Lucas, da Silva Igor, Santana Filho Paulo, Júnior Luiz Carlos Rodrigues, Peres Alessandra, Gonçalves da Fonseca Simone, Chagas Monteiro Marta, Lira Fabio S, Andrey Cipriani Frade Marco, Comerlato Juliana, Comerlato Carolina, Sant'Anna Fernando Hayashi, Bessel Marina, Abreu Celina Monteiro, Wendland Eliana M, Dorneles Gilson P

Abstract excerpt

Monocytes play a major role in the initial innate immune response to SARS-CoV-2. Although viral load may correlate with several clinical outcomes in COVID-19, much less is known regarding their impact on innate immune phenotype. We evaluated the monocyte phenotype and mitochondrial function in severe COVID-19 patients (n = 22) with different viral burden (determined by the median of viral load of the patients) at...

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Identifiers

PMID: 35405594
DOI: 10.1016/j.intimp.2022.108697
PMCID: PMC8920784

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