Article

An efficient and stable ascorbate/O <sub>2</sub> ‑driven route for L‑DOPA synthesis by heme‑dependent tyrosine hydroxylase

2026-04-28

Abstract excerpt

L-DOPA is a key therapeutic agent for Parkinson’s disease, with growing demand due to global population aging. Here we report that heme-dependent tyrosine hydroxylase (TyrH) can utilize an ascorbate/O 2 system—as an alternative to H 2 O 2 —to synthesize L-DOPA with markedly enhanced operational stability. While exogenous H 2 O 2 rapidly inactivates TyrH within minutes, sodium ascorbate (NaAsc) enables sustain...

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Literature Corpus work: 0559b417-9f7e-536c-b474-9e3d7b04d0a7
DOI: 10.64898/2026.04.24.720734

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