Article
Finding Rare, Disease-Associated Variants in Isolated Groups: Potential Advantages of Mennonite Populations.
Human biology - 1 Apr 2016
Lopes Fabiana L, Hou Liping, Boldt Angelica B W, Kassem Layla, Alves Veronica M, Nardi Antonio E, McMahon Francis J
Abstract excerpt
Large-scale genotyping and next-generation sequencing techniques have allowed great advances in the field of molecular genetics. Numerous common variants of low impact have been associated with many complex human traits and diseases, such as bipolar disorder and schizophrenia. Although they may exert a greater impact on risk, few rare disease variants have been found, owing to the greatly increased sample sizes...
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