Article
Genetic architecture in Greenland is shaped by demography, structure and selection.
Nature - 1 Mar 2025
Stæger Frederik Filip, Andersen Mette K, Li Zilong, Hjerresen Jasmin Pernille, He Shixu, Santander Cindy G, Jensen Rasmus Tanderup, Rex Karsten Fleischer, Thuesen Anne Cathrine Baun, Hanghøj Kristian, Seiding Inge Høst, Jørsboe Emil, Stinson Sara Elizabeth, Rasmussen Malthe Sebro, Balboa Renzo F, Larsen Christina Viskum Lytken, Bjerregaard Peter, Schubert Mikkel, Meisner Jonas, Linneberg Allan, Grarup Niels, Zeggini Eleftheria, Nielsen Rasmus, Jørgensen Marit E, Hansen Torben, Moltke Ida, Albrechtsen Anders
Abstract excerpt
Greenlandic Inuit and other indigenous populations are underrepresented in genetic research1,2, leading to inequity in healthcare opportunities. To address this, we performed analyses of sequenced or imputed genomes of 5,996 Greenlanders with extensive phenotypes. We quantified their historical population bottleneck and how it has shaped their genetic architecture to have fewer, but more common, variable sites....
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