Article
Clinically relevant mutations that cause derepression of the Neisseria gonorrhoeae MtrC-MtrD-MtrE Efflux pump system confer different levels of antimicrobial resistance and in vivo fitness.
Molecular microbiology - 1 Oct 2008
Warner Douglas M, Shafer William M, Jerse Ann E
Abstract excerpt
The MtrC-MtrD-MtrE efflux pump system confers resistance to macrolide antibiotics and antimicrobial substances of the host innate defence. Clinical isolates with increased resistance to erythromycin and azithromycin frequently harbour mutations in the mtrR structural gene, which encodes a repressor of the mtrCDE operon, or the mtrR promoter region. The MtrC-MtrD-MtrE system is important for gonococcal survival in...
Topics
- Animals
- Anti-Bacterial Agents
- Antimicrobial Cationic Peptides
- Azithromycin
- Bacterial Outer Membrane Proteins
- Bacterial Proteins
- Drug Resistance, Bacterial
- Erythromycin
- Female
- Gene Expression Profiling
- Gonorrhea
- Lipoproteins
- Membrane Proteins