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A highly potent, orally bioavailable pyrazole-derived cannabinoid CB2 receptor-selective full agonist for <i>in vivo</i> studies

2024-04-29

Abstract excerpt

The cannabinoid CB2 receptor (CB2R) is a potential therapeutic target for distinct forms of tissue injury and inflammatory diseases. To thoroughly investigate the role of CB2R in pathophysiological conditions and for target validation in vivo , optimal pharmacological tool compounds are essential. Despite the sizable progress in the generation of potent and selective CB2R ligands, pharmacokinetic parameters are o...

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Literature Corpus work
04d0120c-9589-5e66-b914-07b6ba0825f6
DOI
10.1101/2024.04.26.591311
Open publication

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A highly potent, orally bioavailable pyrazole-derived cannabinoid CB2 receptor-selective full agonist for <i>in vivo</i> studiesDOI 10.1101/2024.04.26.591311
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