Article
Targeting the cannabinoid CB2 receptor: mutations, modeling and development of CB2 selective ligands.
Current medicinal chemistry - 1 Jan 2005
Raitio K H, Salo O M H, Nevalainen T, Poso A, Järvinen T
Abstract excerpt
Since the discovery of the cannabinoid CB2 receptor in 1993, there has been a growing interest to clarify the importance of this G-protein coupled receptor (GPCR) for human physiology, and to investigate it as a possible target for current and future drug development. Several mutation studies have examined the receptor activation and structure of the receptor binding cavity. Additionally, 3D models for the CB2...
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