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Large-scale biosynthetic analysis of human microbiomes reveals diverse protective ribosomal peptides

28 Mar 2025

Abstract excerpt

The human microbiome produces diverse metabolites that influence host health, yet the chemical landscape of ribosomally synthesized and post-translationally modified peptides (RiPPs)—a versatile class of bioactive compounds—remains underexplored. Here, we conduct a large-scale biosynthetic analysis of 306,481 microbial genomes from human-associated microbiomes, uncovering a broad array of yet-to-be-discovered...

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PMID: 40155374
DOI: 10.1038/s41467-025-58280-w

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