Article

Trans-Omics analysis of post injury thrombo-inflammation identifies endotypes and trajectories in trauma patients

2023-08-18

Abstract excerpt

<h4>ABSTRACT</h4> Understanding and managing the complexity of trauma-induced thrombo-inflammation necessitates an innovative, data-driven approach. This study leveraged a trans-omics analysis of longitudinal samples from trauma patients to illuminate molecular endotypes and trajectories that underpin patient outcomes. We hypothesized that trans-omics profiling reveals underlying clinical differences in severely...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8dec82de-2466-5ffe-94c8-451818e971f9
DOI: 10.1101/2023.08.16.553446

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Trans-Omics analysis of post injury thrombo-inflammation identifies endotypes and trajectories in trauma patientsDOI 10.1101/2023.08.16.553446Read

Dissecting Inflammatory Complications in Critically Injured Patients by Within-Patient Gene Expression Changes: A Longitudinal Clinical Genomics StudySemantic proximity Read

Development of clinical phenotypes and biological profiles via proteomic analysis of trauma patients.Semantic proximity Read

Computational Derivation of Core, Dynamic Human Blunt Trauma Inflammatory Endotypes.Semantic proximity Read

Integrating Machine Learning with Metabolic Models for Precision Trauma Care: Personalized ENDOTYPE Stratification and Metabolic Target IdentificationSemantic proximity Read

Integrating Machine Learning with Metabolic Models for Precision Trauma Care: Personalized ENDOTYPE Stratification and Metabolic Target IdentificationSemantic proximity Read

Development of a predictive algorithm for patient survival after traumatic injury using a five analyte blood panelSemantic proximity Read

Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort studySemantic proximity Read

International multi-cohort analysis identifies novel framework for quantifying immune dysregulation in critical illness: results of the SUBSPACE consortiumSemantic proximity Read

Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits.Semantic proximity Read

High-dimensional proteomics identifies organ injury patterns associated with outcomes in human traumaSemantic proximity Read

High-throughput mass spectrometry maps the sepsis plasma proteome and differences in responseSemantic proximity Read

Prehospital plasma is associated with distinct biomarker expression following injurySemantic proximity Read