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Article

Computational Derivation of Core, Dynamic Human Blunt Trauma Inflammatory Endotypes.

Frontiers in immunology - 1 Jan 2020

Schimunek Lukas, Lindberg Haley, Cohen Maria, Namas Rami A, Mi Qi, Yin Jinling, Barclay Derek, El-Dehaibi Fayten, Abboud Andrew, Zamora Ruben, Billiar Timothy Robert, Vodovotz Yoram

Abstract excerpt

Systemic inflammation ensues following traumatic injury, driving immune dysregulation and multiple organ dysfunction (MOD). While a balanced immune/inflammatory response is ideal for promoting tissue regeneration, most trauma patients exhibit variable and either overly exuberant or overly damped responses that likely drive adverse clinical outcomes. We hypothesized that these inflammatory phenotypes occur in the...

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Identifiers

PMID: 33537029
DOI: 10.3389/fimmu.2020.589304
PMCID: PMC7848165

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