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Article

Alcohol exposure disrupts mu opioid receptor-mediated long-term depression at insular cortex inputs to dorsolateral striatum.

Nature communications - 3 Apr 2018

Muñoz Braulio, Fritz Brandon M, Yin Fuqin, Atwood Brady K

Abstract excerpt

Drugs of abuse, including alcohol, ablate the expression of specific forms of long-term synaptic depression (LTD) at glutamatergic synapses in dorsal striatum (DS), a brain region involved in goal-directed and habitual behaviors. This loss of LTD is associated with altered DS-dependent behavior. Given the role of the µ-opioid receptor (MOR) in behavioral responding for alcohol, we explored the impact of alcohol...

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Identifiers

PMID: 29615610
DOI: 10.1038/s41467-018-03683-1
PMCID: PMC5882774

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