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Article

The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia.

Blood - 26 Jan 2017

Li Hubo, Mar Brenton G, Zhang Huadi, Puram Rishi V, Vazquez Francisca, Weir Barbara A, Hahn William C, Ebert Benjamin, Pellman David

Abstract excerpt

Acute myeloid leukemia (AML) is a heterogeneous disease with complex molecular pathophysiology. To systematically characterize AML's genetic dependencies, we conducted genome-scale short hairpin RNA screens in 17 AML cell lines and analyzed dependencies relative to parallel screens in 199 cell lines of other cancer types. We identified 353 genes specifically required for AML cell proliferation. To validate the in...

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Topics

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Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial-Mesenchymal Transition

Share to Homeodomain Proteins

Share to Leukemia, Myeloid, Acute

Share to Oncogene Proteins, Fusion

Share to RNA, Small Interfering

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Source

Open in PubMed Open full text

Identifiers

PMID: 27756750
DOI: 10.1182/blood-2016-05-714493
PMCID: PMC5270388

Genes

ZEB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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