Article

Lineage memory shapes viral resistance barriers in human skin

2025-06-27

Abstract excerpt

Individual cells within a given population exhibit striking variability in viral susceptibility, but it remains unknown whether this heterogeneity reflects memories encoded into the cellular lineage or true probabilistic variability. We used multi-color lineage tracing in a human primary organotypic skin model to reveal that viral resistance is encoded within specific cellular lineages. These lineages create disti...

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Literature Corpus work: 0461a0cf-dad1-5db4-b977-ec5c9c0c1c9e
DOI: 10.1101/2025.06.27.661951

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