Article

Profilin-1 Promotes Chromophobe Renal Cell Carcinoma Malignancy

2026-05-14

Abstract excerpt

<h4>ABSTRACT</h4> Chromophobe renal cell carcinoma (ChRCC) accounts for 5% of all renal cancer cases. Despite its generally indolent behavior and low mutational burden, there is no targeted therapy for metastatic ChRCC. Profilin-1 (Pfn1), a cytoskeletal regulator of actin and tubulin dynamics, has emerged as a potential oncogenic driver in several cancers including RCC, but its role in ChRCC, remains undefined. W...

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Literature Corpus work: 04556597-981d-5f67-8edd-3c9d4abb427c
DOI: 10.64898/2026.05.11.723846

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