NF2-mutated Renal Cell Carcinoma: Clinicopathologic and Molecular Characterization of Two Additional Tumors Highlighting Morphologic Heterogeneity and Potential Aggressive Behavior.

Abstract excerpt

NF2 gene alterations are significant drivers in a subset of renal cell carcinomas (RCCs), associated with high-grade morphology, aggressive behavior, and features overlapping with biphasic hyalinizing psammomatous RCC (BHP RCC). We report two examples of NF2-mutated RCC to advance understanding of this entity. Both were female patients in their sixth decade with incidental, solid renal masses (3.2 and 3.0 cm)....

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• Biomarkers, Tumor
• Carcinoma, Renal Cell
• PAX8 gene
• Immunohistochemistry
• Kidney