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Article

Eosinophilic Pattern of Chromophobe Renal Cell Carcinoma is More Aggressive Than the Classic Pattern: A Comprehensive Morphologic and Genomic Analysis.

The American journal of surgical pathology - 1 Aug 2026

Zakhary Abraam, Castillo Vincent F P, Trpkov Kiril, Morgan Joy, Plant Pamela, Mimosa Mashiat, Patel Shreya, El-Mallah Mark, Downes Michelle R, Yousef George M, Pace Kenneth, Hamdani Malek, Saleeb Rola M

Abstract excerpt

Chromophobe renal cell carcinoma (chRCC) is generally considered an indolent malignancy; however, studies have produced conflicting results regarding the differences among its histologic patterns. The prognostic significance of eosinophilic morphology in chRCC remains controversial, in part due to inconsistent diagnostic criteria and inclusion of morphologic mimickers. Cases were classified by 3 expert...

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Identifiers

PMID: 42023719
DOI: 10.1097/PAS.0000000000002560

Genes

RB1
PTEN
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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