PARP-1 selectively impairs KRAS-driven phenotypic and molecular features in intrahepatic cholangiocarcinoma.

doi:10.1136/gutjnl-2023-331237

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Article

PARP-1 selectively impairs KRAS-driven phenotypic and molecular features in intrahepatic cholangiocarcinoma.

Gut - 9 Sept 2024

Keggenhoff Friederike L, Castven Darko, Becker Diana, Stojkovic Stojan, Castven Jovana, Zimpel Carolin, Straub Beate K, Gerber Tiemo, Langer Harald, Hähnel Patricia, Kindler Thomas, Fahrer Jörg, O'Rourke Colm J, Ehmer Ursula, Saborowski Anna, Ma Lichun, Wang Xin Wei, Gaiser Timo, Matter Matthias S, Sina Christian, Derer Stefanie, Lee Ju-Seog, Roessler Stephanie, Kaina Bernd, Andersen Jesper B, Galle Peter R, Marquardt Jens U

Abstract excerpt

OBJECTIVE: Intrahepatic cholangiocarcinoma (iCCA) is the second most common primary liver cancer with limited therapeutic options. KRAS mutations are among the most abundant genetic alterations in iCCA associated with poor clinical outcome and treatment response. Recent findings indicate that Poly(ADP-ribose)polymerase1 (PARP-1) is implicated in KRAS-driven cancers, but its exact role in cholangiocarcinogenesis...

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Identifiers

PMID: 38857989
DOI: 10.1136/gutjnl-2023-331237
PMCID: PMC11420749

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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