Article

A role for astrocytic miR-129-5p in Frontotemporal Dementia

2024-04-19

Abstract excerpt

Frontotemporal dementia is a debilitating neurodegenerative disorder characterized by frontal and temporal lobe degeneration, resulting in behavioral changes, language difficulties, and cognitive decline. In this study, smallRNA sequencing was conducted on postmortem brain tissues obtained from FTD patients with GRN , MAPT , or C9ORF72 mutations, focusing on the frontal and temporal lobes. Our analysis identifi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 041ca79c-aee3-5d72-933b-0025862866f0
DOI: 10.1101/2024.04.15.589528

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A role for astrocytic miR-129-5p in Frontotemporal DementiaDOI 10.1101/2024.04.15.589528Read

Inhibition of MicroRNA-129-5p Promotes Neuroinflammation and Cognitive ImpairmentSemantic proximity Read

Involvement of Astrocytes and microRNA Dysregulation in Neurodegenerative Diseases: From Pathogenesis to Therapeutic PotentialSemantic proximity Read

Astrocytes in Alzheimer´s Disease: Pathological Significance and Molecular PathwaysSemantic proximity Read

Astrocytes in Alzheimer’s Disease: Pathological Significance and Molecular PathwaysSemantic proximity Read

Molecular basis of astrocyte diversity and morphology across the CNS in health and diseaseSemantic proximity Read

Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by single-nucleus RNA sequencing of human cerebral cortex.Semantic proximity Read

Astrocyte transcriptomic analysis identifies glypican 5 downregulation as a contributor to synaptic dysfunction in Alzheimer’s disease modelsSemantic proximity Read

Cholesterol Dysregulation in APOE4 Astrocytes Promotes α-Synuclein Pathology in miBrains, a Human Brain Tissue ModelSemantic proximity Read

Deletion of astrocyte intermediate filaments GFAP and Vimentin enhances protein synthesis and prevents early synaptic and cognitive dysfunction in a mouse model of Alzheimer’s diseaseSemantic proximity Read

The Role of White Matter Dysfunction and Leukoencephalopathy/Leukodystrophy Genes in the Aetiology of Frontotemporal Dementias: Implications for Novel Approaches to Therapeutics.Semantic proximity Read

Astrocyte dysfunction and neuronal network hyperactivity in a CRISPR engineered pluripotent stem cell model of frontotemporal dementiaSemantic proximity Read

Single-nucleus multiomic atlas of ALS primary motor cortex nominates neuroprotective WDR49-expressing astrocytesSemantic proximity Read