Article

Brucine-induced neurotoxicity by targeting caspase 3: Involvement of PPARγ/NF- κB/apoptosis signaling pathway

2022-08-08

Abstract excerpt

Brucine, a weak alkaline indole alkaloid, is one of the main bioactive and toxic constituents of Strychnos nux-vomica L., which exerts multiple pharmacological activities, such as anti-tumor, anti-inflammatory, analgesic effect. However, its potential toxic effects limited its clinical application, especially central nervous system toxicity. The present study was designed to investigate the neurotoxicity and mecha...

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Literature Corpus work: 0405e306-5d38-5866-8b9f-6c9ccb6f6777
DOI: 10.21203/rs.3.rs-1747852/v2

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