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Mitigating Proinflammatory SASP and DAMP with Urolithin A: A Novel Senomorphic Strategy

2025-01-08

Abstract excerpt

Senescent cells are known to contribute to aging and age-related diseases. One key way they influence aging is by secreting senescence-associated secretory phenotype (SASP) factors along with several damage-associated molecular pattern (DAMP) molecules. Consequently, inhibiting SASP and DAMP signaling (senomorphics) has emerged as a therapeutic strategy. Urolithin A (UA), a gut-derived metabolite produced from ell...

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Identifiers and source

Literature Corpus work
03d54c85-2420-5461-8869-93131bd450d0
DOI
10.1101/2025.01.07.631588
Open publication

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Mitigating Proinflammatory SASP and DAMP with Urolithin A: A Novel Senomorphic StrategyDOI 10.1101/2025.01.07.631588
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