Article

Effect of naturally-occurring mutations on the stability and function of cancer-associated NQO1: comparison of experiments and computation

2022-10-03

Abstract excerpt

Recent advances in DNA sequencing technologies are revealing a large variability in the human genome. Our capacity to establish genotype-phenotype correlations in such large-scale is, however, limited. This task is particularly challenging due to the multifunctional nature of proteins. Here we describe an extensive analysis of the stability and function of naturally-occurring variants (found in the COSMIC and gnom...

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Literature Corpus work: 03b1894b-f08d-5236-bdae-0aee01fc0572
DOI: 10.1101/2022.09.30.510258

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