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Article

Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution.

Human molecular genetics - 15 Sept 2017

Medina-Carmona Encarnación, Fuchs Julian E, Gavira Jose A, Mesa-Torres Noel, Neira Jose L, Salido Eduardo, Palomino-Morales Rogelio, Burgos Miguel, Timson David J, Pey Angel L

Abstract excerpt

Human proteins are vulnerable towards disease-associated single amino acid replacements affecting protein stability and function. Interestingly, a few studies have shown that consensus amino acids from mammals or vertebrates can enhance protein stability when incorporated into human proteins. Here, we investigate yet unexplored relationships between the high vulnerability of human proteins towards...

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Source

Identifiers

PMID: 28911204
DOI: 10.1093/hmg/ddx238

Genes

NQO1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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