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B4GALNT3 regulates glycosylation of sclerostin and bone mass

5 Apr 2023

Abstract excerpt

BACKGROUND: Global sclerostin inhibition reduces fracture risk efficiently but has been associated with cardiovascular side effects. The strongest genetic signal for circulating sclerostin is in the B4GALNT3 gene region, but the causal gene is unknown. B4GALNT3 expresses the enzyme beta-1,4-N-acetylgalactosaminyltransferase 3 that transfers N-acetylgalactosamine onto N-acetylglucosaminebeta-benzyl on protein...

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PMID: 37023531
DOI: 10.1016/j.ebiom.2023.104546

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