Article
Association between rare variants in specific functional pathways and human neural tube defects multiple subphenotypes.
Neural development - 10 Jul 2020
Zou Jizhen, Wang Fang, Yang Xueyan, Wang Hongyan, Niswander Lee, Zhang Ting, Li Huili
Abstract excerpt
BACKGROUND: Neural tube defects (NTDs) are failure of neural tube closure, which includes multiple central nervous system phenotypes. More than 300 mouse mutant strains exhibits NTDs phenotypes and give us some clues to establish association between biological functions and subphenotypes. However, the knowledge about association in human remains still very poor. METHODS: High throughput targeted genome DNA...
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