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Article

PET, image-guided HDAC inhibition of pediatric diffuse midline glioma improves survival in murine models

24 Jul 2020

Abstract excerpt

Efforts at altering the dismal prognosis of pediatric midline gliomas focus on direct delivery strategies like convection-enhanced delivery (CED), where a cannula is implanted into tumor. Successful CED treatments require confirmation of tumor coverage, dosimetry, and longitudinal in vivo pharmacokinetic monitoring. These properties would be best determined clinically with image-guided dosimetry using theranostic...

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PMID: 32832670
DOI: 10.1126/sciadv.abb4105

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