Article

ZNF865 Regulates Senescence and Cell Cycle for Applications to Cell Engineering and Gene Therapy

2023-10-29

Abstract excerpt

Zinc finger (ZNF) proteins represent the largest group of regulatory proteins within eukaryotic genomes. However, despite their broad regulatory function, the majority of ZNF protein function remains unknown. Recently, we discovered ZNF865, which has no in-depth publications and has not been functionally characterized. Utilizing CRISPR-guided gene modulation, we show that ZNF865 regulates key cellular and molecula...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 03623b5a-f411-54a7-997e-55ddd5539e9a
DOI: 10.1101/2023.10.25.563801

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ZNF865 Regulates Senescence and Cell Cycle for Applications to Cell Engineering and Gene TherapyDOI 10.1101/2023.10.25.563801Read

ZNF865 (BLST) a Novel Regulator of DNA Damage and Cell Senescence in Back PainSemantic proximity Read

The age-regulated zinc finger factor ZNF367 is a new modulator of embryonic neurogenesisSemantic proximity Read

ZNF768 links oncogenic RAS to cellular senescence.Semantic proximity Read

Zinc finger proteins: guardians of genome stabilitySemantic proximity Read

The cGAS-STING pathway affects vertebral bone but does not promote intervertebral disc cell senescence or degenerationSemantic proximity Read

Transcription factor ZNF148 is a negative regulator of human muscle differentiation.Semantic proximity Read

FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere UncappingSemantic proximity Read

Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenationSemantic proximity Read

CRISPR screens identify targets to rescue age-related T cell dysfunction in cancerSemantic proximity Read

Single-cell protein activity analysis reveals a novel subpopulation of chondrocytes and the corresponding key master regulator proteins associated with anti-senescence and OA progressionSemantic proximity Read

Chemogenetic profiling of ubiquitin-like modifier pathways identifies NFATC2IP as a mediator of SUMO-dependent genome integritySemantic proximity Read

Fibro-NPC: a pathogenic subtype identified at single-cell resolution with secreted SFRP4 as a biomarker in intervertebral disc degenerationSemantic proximity Read