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CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer

2026-01-24

Abstract excerpt

Immune aging is being increasingly recognized as a critical barrier to effective cancer immunotherapy, as the aged tumor microenvironment (TME) drives T cell dysfunction and impairs immune control of cancer 1–4 . However, the key molecular drivers of this process as well as potential targets to rescue T cell dysfunction in aged tumors remain incompletely understood. Therefore, we performed in vivo single-cell CRI...

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Literature Corpus work
8eefeb2b-0ab7-58a6-959b-a0a8dc2afa07
DOI
10.64898/2026.01.22.701075
Open publication

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