Article

Recruitment of FBXO22 for Targeted Degradation of NSD2

2023-11-02

Abstract excerpt

Targeted protein degradation (TPD) is an emerging therapeutic strategy that would benefit from new chemical entities with which to recruit a wider variety of ubiquitin E3 ligases to target proteins for proteasomal degradation. Here, we describe a TPD strategy involving the recruitment of FBXO22 to induce degradation of the histone methyltransferase and oncogene NSD2. UNC8732 facilitates FBXO22-mediated degradation...

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Literature Corpus work: 03388dba-f1a5-5482-8b64-e9f69d27b68c
DOI: 10.1101/2023.11.01.564830

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