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Probenecid inhibits SARS-CoV-2 replication in vivo and in vitro

10 Sept 2021

Abstract excerpt

Abstract Effective vaccines are slowing the COVID-19 pandemic, but SARS-CoV-2 will likely remain an issue in the future making it important to have therapeutics to treat patients. There are few options for treating patients with COVID-19. We show probenecid potently blocks SARS-CoV-2 replication in mammalian cells and virus replication in a hamster model. Furthermore, we demonstrate that plasma concentrations up...

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PMID: 34508172
DOI: 10.1038/s41598-021-97658-w

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