Article

Alpha globin gene copy number and hypertension risk among Black Americans

2022-02-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Alpha globin is expressed in the endothelial cells of human resistance arteries where it binds to endothelial nitric oxide synthase and limits release of the vasodilator nitric oxide. Genomic deletion of the alpha globin gene ( HBA ) is common among Black Americans and could lead to increased endothelial nitric oxide signaling and reduced risk of hypertension. <h4>METHODS</h4>...

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Literature Corpus work: 02f11b03-e07d-5e1c-a8e9-a50953cdebe1
DOI: 10.1101/2022.02.02.22269915

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