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Article

Association of alpha globin gene copy number with exhaled nitric oxide in a cross-sectional study of healthy Black adults.

BMJ open respiratory research - 20 Dec 2023

Ruhl A Parker, Jackson Jarrett M, Carhuas Carlos J, Niño de Rivera Jessica G, Fay Michael P, Weinberg J Brice, Que Loretta G, Ackerman Hans C

Abstract excerpt

INTRODUCTION: The genetic determinants of fractional exhalation of nitric oxide (FeNO), a marker of lung inflammation, are understudied in Black individuals. Alpha globin (HBA) restricts nitric oxide signalling in arterial endothelial cells via interactions with nitric oxide synthase; however, its role in regulating the release of NO from respiratory epithelium is less well understood. We hypothesised that an HBA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38123476
DOI: 10.1136/bmjresp-2023-001714

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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