Article

CENO: A Genome-Scale World Model for Evolutionary Sequence Interpretation and Programmable Regulatory Design

2026-07-30

Abstract excerpt

DNA encodes biological function across a continuum of sequence scales, from single-nucleotide and motif-level grammar to regulatory neighborhoods, chromatin-scale organization and evolutionary constraint. A useful model of genomes should therefore do more than classify short sequence windows: it should maintain nucleotide-resolution state over long contexts, score counterfactual mutations, condition on homologous...

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Literature Corpus work: 02ddab65-cebd-5151-95ca-3896b92cb653
DOI: 10.64898/2026.07.28.741284

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