Article

Benchmarking DNA Foundation Models for zero-shot variant effect prediction: the role of context, training, and architecture

2025-06-19

Abstract excerpt

In this study, we systematically evaluate the performance of several DNA foundation models (NT, DNABERT, and HyenaDNA) in predicting the functional impact of genetic variants using Zero-shot scoring, a method that does not require task-specific fine-tuning. We assess the models’ sensitivity to sequence alterations introduced by Single Nucleotide Variants (SNVs), comparing their ability to capture both local and ex...

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Literature Corpus work: 51e041bc-cd73-5e4a-8925-390267483e3f
DOI: 10.1101/2025.06.15.659748

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