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Benchmarking DNA Foundation Models for zero-shot variant effect prediction: the role of context, training, and architecture

2025-08-05

Abstract excerpt

<title>Abstract</title> <p>In this study, we systematically evaluate the performance of several DNA foundation models (NT, DNABERT, and HyenaDNA) in predicting the functional impact of genetic variants using Zero-shot scoring, a method that does not require task-specific fine-tuning. We assess the models’ sensitivity to sequence alterations introduced by Single Nucleotide Variants (SNVs), comparing their ability...

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Literature Corpus work: 0fc42d86-d36c-591e-86b4-d73cae7370bc
DOI: 10.21203/rs.3.rs-6988910/v1

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