Article

Preconditioning Matters: Enhancing or Impairing Antitumor Immunity with DC Vaccines

2025-05-08

Abstract excerpt

Preconditioning regimens are essential for the success of adoptive cell therapies like CAR T-cells due to effects on the T-cell response, yet they are underexplored and generally absent from cancer vaccine clinical trials. To address this gap, we evaluated the impact of various preconditioning strategies on dendritic cell (DC) vaccine efficacy in a murine tumor model. Mice bearing syngeneic KP tumors expressing ov...

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Literature Corpus work: 02bfdc2e-1890-5635-a0a5-dac88997c6b5
DOI: 10.1101/2025.05.02.651990

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