Article

Breast Cancers That Disseminate to Bone Marrow Acquire Aggressive Phenotypes through CX43-related Tumor-Stroma Tunnels

2023-03-21

Abstract excerpt

Estrogen receptor-positive (ER+) breast cancer commonly disseminates to bone marrow, where interactions with mesenchymal stromal cells (MSCs) shape disease trajectory. We modeled these interactions with tumor-MSC co-cultures and used an integrated transcriptome-proteome-network-analyses workflow to identify a comprehensive catalog of contact-induced changes. Conditioned media from MSCs failed to recapitulate genes...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 02afe509-e8d9-5298-9e88-f77af988a864
DOI: 10.1101/2023.03.18.533175

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Breast Cancers That Disseminate to Bone Marrow Acquire Aggressive Phenotypes through CX43-related Tumor-Stroma TunnelsDOI 10.1101/2023.03.18.533175Read

Breast cancers that disseminate to bone marrow acquire aggressive phenotypes through CX43-related tumor-stroma tunnelsSemantic proximity Read

Communication Breakdown and Evolution of the Cancer CellSemantic proximity Read

Integrative Single-cell and Spatial Transcriptomic Analysis of Osteosarcoma Reveals Conserved and Distinct Ecosystems Across Sites and SpeciesSemantic proximity Read

Tunneling nanotubes propagate preneoplastic cues in a BMP-dependent mannerSemantic proximity Read

3-D Vascularized Breast Cancer Model to Study the Role of Osteoblast in Formation of a Pre-Metastatic NicheSemantic proximity Read

Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell functionSemantic proximity Read

A Ticket to Ride: The Implications of Direct Intercellular Communication via Tunneling Nanotubes in Peritoneal and Other Invasive MalignanciesSemantic proximity Read

Characterization of extracellular vesicle-associated DNA and proteins derived from organotropic metastatic breast cancer cellsSemantic proximity Read

Deciphering Stromal Changes between Metastatic and Non-metastatic Canine Mammary CarcinomasSemantic proximity Read

Malignant canine mammary epithelial cells shed exosomes containing differentially expressed microRNA that regulate oncogenic networksSemantic proximity Read

Breast cancer ovarian metastases show increased activity of GPCR pathwaysSemantic proximity Read

Breast cancer interactions with osteoclasts generate osteoclast-tumor hybrid-like cells through dynamic non-canonical cell fusion and cell-in-cell processesSemantic proximity Read