Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Breast cancers that disseminate to bone marrow acquire aggressive phenotypes through CX43-related tumor-stroma tunnels

31 Oct 2024

Abstract excerpt

Estrogen receptor-positive (ER+) breast cancer commonly disseminates to bone marrow, where interactions with mesenchymal stromal cells (MSCs) shape disease trajectory. We modeled these interactions with tumor-MSC co-cultures and used an integrated transcriptome-proteome-network-analyses workflow to identify a comprehensive catalog of contact-induced changes. Conditioned media from MSCs failed to recapitulate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Chemokine receptors and signaling
Share to Glycosylation and Glycoproteins Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39480488
DOI: 10.1172/jci170953

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Breast cancers that disseminate to bone marrow acquire aggressive phenotypes through CX43-related tumor-stroma tunnelsPMID 39480488Read ↗

Breast Cancers That Disseminate to Bone Marrow Acquire Aggressive Phenotypes through CX43-related Tumor-Stroma TunnelsSemantic proximity Read ↗

Communication Breakdown and Evolution of the Cancer CellSemantic proximity Read ↗

Integrative Single-cell and Spatial Transcriptomic Analysis of Osteosarcoma Reveals Conserved and Distinct Ecosystems Across Sites and SpeciesSemantic proximity Read ↗

Tunneling nanotubes propagate preneoplastic cues in a BMP-dependent mannerSemantic proximity Read ↗

3-D Vascularized Breast Cancer Model to Study the Role of Osteoblast in Formation of a Pre-Metastatic NicheSemantic proximity Read ↗

Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell functionSemantic proximity Read ↗

Characterization of extracellular vesicle-associated DNA and proteins derived from organotropic metastatic breast cancer cellsSemantic proximity Read ↗

A Ticket to Ride: The Implications of Direct Intercellular Communication via Tunneling Nanotubes in Peritoneal and Other Invasive MalignanciesSemantic proximity Read ↗

Deciphering Stromal Changes between Metastatic and Non-metastatic Canine Mammary CarcinomasSemantic proximity Read ↗

Malignant canine mammary epithelial cells shed exosomes containing differentially expressed microRNA that regulate oncogenic networksSemantic proximity Read ↗

Breast cancer ovarian metastases show increased activity of GPCR pathwaysSemantic proximity Read ↗

ICELLNET: a transcriptome-based framework to dissect intercellular communicationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.