Article

Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein

2019-07-12

Abstract excerpt

α-Synuclein (aSyn) aggregation is thought to play a central role in neurodegenerative disorders termed synucleinopathies, including Parkinson’s disease (PD). Mouse aSyn contains a threonine residue at position 53 that mimics the human familial PD substitution A53T, yet in contrast to A53T patients, mice show no evidence of aSyn neuropathology even after aging. Here we studied the neurotoxicity of human A53T, mouse...

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Literature Corpus work: 02861273-61a5-5a08-858c-03d900fe6f05
DOI: 10.1101/700377

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